I'm running 295/30R24 on my 24x10 rims. Only downside is availability and choice of manufactures. Toyo and Pirelli are the only "name brands" that offer that size. Then you have Durun, Fullrun (Fullway whatever), and maybe 1 or 2 other Korean brands.
I bought the Duruns and they seem to be a decent tire. But for half the price of the Toyo and Pirelli, and how my truck won't see 5k miles a year I said f*ck it.